Pathogenesis of ovine footrot disease: a complex picture.
نویسندگان
چکیده
منابع مشابه
First study of pathogen load and localisation of ovine footrot using fluorescence in situ hybridisation (FISH)
Analysis of bacterial populations in situ provides insights into pathogen population dynamics and potential reservoirs for disease. Here we report a culture-independent study of ovine footrot (FR); a debilitating bacterial disease that has significant economic impact on sheep farming worldwide. Disease begins as an interdigital dermatitis (ID), which may then progress to separation of the hoof ...
متن کاملDifferential expression of Toll-like receptors and inflammatory cytokines in ovine interdigital dermatitis and footrot
Footrot is a common inflammatory bacterial disease affecting the health and welfare of sheep worldwide. The pathogenesis of footrot is complex and multifactorial. The primary causal pathogen is the anaerobic bacterium Dichelobacter nodosus, with Fusobacterium necrophorum also shown to play a key role in disease. Since immune-mediated pathology is implicated, the aim of this research was to inve...
متن کاملDichelobacter nodosus and Footrot in Swedish Sheep Increased Knowledge and Improved Laboratory Diagnostics
Ovine footrot is a contagious bacterial disease primarily caused by Dichelobacter nodosus. Footrot affects the feet of sheep and is characterised by two major clinical presentations. The milder form consists of inflammation confined to the interdigital space (interdigital dermatitis or benign footrot) and the more severe form includes underrunning of the hoof horn (underrunning or virulent foot...
متن کاملA distinct bacterial dysbiosis associated skin inflammation in ovine footrot
Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in fo...
متن کاملMathematical modeling of ovine footrot in the UK: the effect of Dichelobacter nodosus and Fusobacterium necrophorum on the disease dynamics
Dichelobacter nodosus is a virulent, invasive, anaerobic bacterium that is believed to be the causative agent of ovine footrot, an infectious bacterial disease of sheep that causes lameness. Another anaerobe, Fusobacterium necrophorum, has been intimately linked with the disease occurrence and severity. Here we examine data from a longitudinal study of footrot on one UK farm, including quantita...
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عنوان ژورنال:
- The Veterinary record
دوره 179 9 شماره
صفحات -
تاریخ انتشار 2016